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CBD and schizophrenia treatment

First research of CBD and its possible anti-psychotic effects on people was carried out on a schizophrenic patient who was suffering from considerable hormonal side-effects while being cured by classical antipsychotics.

The patient was a 19 years old woman who was undergoing a treatment on a clinic Riberao Preto. She suffered from aggressivity, self-harm, incoherent thinking and auditory hallucinations (Zuardi et al. 1995). CBD was given to her gradually, in increased doses, to up to 1500 mg, in 2 doses a day within 4 weeks. Then, the CBD doses were replaced by placebo. After that, the patient was given haloperidol in doses that were matching her current state. In the highest level of distractibility, the patient was given diazepam. 

The average daily dose of diazepam decreased while taking CBD from 16,3 to 5,7mg.

The patient was under continuous supervision by 2 doctors and 2 nurses and was also continuously recorded. After the experiment has ended, random recording sequences were analyzed by independent psychiatrist with following conclusion: The schizophrenia symptoms have diminished during CBD intake and on the contrary they have increased after CBD withdrawal. The improvement caused by CBD intake was not enhanced by haloperidol. Improvement of the patient´s state was observed in all areas including psychotic symptoms.

CBD and psychosis by Parkinson´s disease

Another opened pilot study at the University in Sao Paolo showed an effective treatment of psychotic symptoms on patients with Parkinson´s thanks to CBD (Zuardi et al. 2008).

6 patients (4 men and 2 women) diagnosed with Parkinson´s disease and psychosis were chosen for this 3-month-study. All patients were given CBD orally, 150mg doses a day in 4 weeks, as a medical supplement during their regular treatment. During this CBD cure, a significant decrease of psychotic symptoms was noted by all patients. CBD, at the same time, did not cause any worsening of motoric functions nor had no other further negative effects.
Authors of this study came to a conclusion that CBD can be effective, well tolerated and secure psychosis treatment by Parkinson´s disease.

CBD and schizophrenia – clinical study on 42 patients

First controlled clinical study of healing CBD potential on schizophrenia was taking place at University in Cologne on 42 patients suffering from acute schizophrenia. Study has shown that CBD intake decreases significantly psychopathic symptoms in comparison to original state (Leweke et al. 2012).
First half of the patients were given 800mg of CBD during 4 weeks and the other half was given the classical antipsychotic - amisulprid. Both treatments lead to significant improvement of clinical symptoms, nevertheless the patients given CBD, suffered from fundamentally less side effects. At the same time, in the CBD group there was a significant improvement of anandamid concentration in patients´ blood.
(Anandamid is an endogenic cannabinoid that, like psychotomimeticaly active THC, connects to the receptors in brain. Anandamid is either neuromodulator or neurotransmitter. This just recently discovered informative molecule plays its role in pain, depression, appetite, memory and fertility.) 

From following study, the authors concluded that “prevention (inhibition) of anandamid deactivation supports antipsychotic effects of CBD which means a significant change in schizophrenia treatment.

Additional information
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